Rapid discontinuation has also been associated with attempts to find other sources of opioid analgesics, which may be confused with drug-seeking for abuse. Rapid discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide. Safe Reduction or Discontinuation of NORCOĭo not abruptly discontinue NORCO in patients who may be physically dependent on opioids. The relative bioavailability of hydrocodone from NORCO compared to extended-release hydrocodone products is unknown, so conversion to extended-release products must be accompanied by close observation for signs of excessive sedation and respiratory depression. It is safer to underestimate a patient’s 24-hour NORCO dosage than to overestimate the 24-hour NORCO dosage and manage an adverse reaction due to overdose.Ĭonversion from NORCO to Extended-Release Hydrocodone Therefore, a conservative approach is advised when determining the total daily dosage of NORCO. There is inter-patient variability in the potency of opioid drugs and opioid formulations.
The total daily dosage should not exceed 6 tablets. The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 8 tablets. The usual adult dosage is one or two tablets every four to six hours as needed for pain. Initiating Treatment with NORCO NORCO 5/325 Ĭonsider prescribing naloxone when the patient has household members (including children) or other close contacts at risk for accidental ingestion or overdose. The presence of risk factors for overdose should not prevent the proper management of pain in any given patient. Inform patients and caregivers about the various ways to obtain naloxone as permitted by individual state naloxone dispensing and prescribing regulations (e.g., by prescription, directly from a pharmacist, or as part of a community-based program).Ĭonsider prescribing naloxone, based on the patient’s risk factors for overdose, such as concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose. Patient Access to Naloxone for the Emergency Treatment of Opioid Overdoseĭiscuss the availability of naloxone for the emergency treatment of opioid overdose with the patient and caregiver and assess the potential need for access to naloxone, both when initiating and renewing treatment with NORCO.
0 kommentar(er)
